As global demand for assisted reproductive technologies rises, in vitro fertilization (IVF) in the United States has become a top choice for many families due to its high success rates, advanced medical standards, and strict regulations. This guide walks you through the entire IVF journey in the U.S.—from initial preparation to embryo transfer—so you can clearly understand each step.
1. Who Is U.S. IVF Suitable For?
U.S. IVF is ideal for individuals or couples in the following situations:
- Women of advanced maternal age (typically over 35)
- Low ovarian reserve
- Recurrent pregnancy failure
- Carriers of genetic disorders (PGT recommended)
- Male infertility (e.g., low sperm count or motility)
- LGBTQ+ individuals or single parents seeking biological children
2. Pre-IVF Preparation
1. Choosing the Right Fertility Clinic
Selecting a clinic is the first crucial step. Some top fertility clinics in the U.S. include:
- INCINTA Fertility Center (renowned for personalized treatment plans and advanced support)
- Other notable options: CCRM, HRC Fertility, SDFC, and more.
Key selection criteria:
- Success rates
- Doctor qualifications
- Lab quality and technology
- Experience with international patients
- Language and logistical support
2. Remote Consultation and Medical Evaluation
Patients can consult doctors via video. Based on medical history and initial test results (e.g., AMH, hormone panel, ultrasound), the clinic will provide an initial assessment.
3. Submitting Medical Records and Booking the IVF Cycle
Commonly required documents include:
- Medical test reports (both partners)
- Previous treatment history
- Passport copies
- Marital certificate (if required)
- Health questionnaires
The clinic will schedule your treatment based on your menstrual cycle.
3. Travel and Logistics for IVF in the U.S.
- Typical Stay Duration: One IVF cycle requires around 18–25 days in the U.S. (excluding PGT or frozen transfer cycles).
- Visa Requirements: B2 medical or tourist visa.
- Accommodation: Many clinics are surrounded by apartments, hotels, or service providers that offer translation and concierge services.
4. Ovarian Stimulation Phase (Day 1–10)
1. Starting Hormonal Medications
Ovarian stimulation typically starts on the 2nd day of the menstrual cycle. Common medications include Gonal-F, Menopur, and Luveris.
2. Monitoring During Stimulation
Regular ultrasound scans and blood tests are conducted to track follicle growth. Dosages are adjusted accordingly.
3. Triggering Ovulation
Once follicles reach optimal size (usually ≥18mm), a trigger shot (HCG or Lupron) is administered, and egg retrieval is scheduled 36 hours later.
5. Egg and Sperm Collection (Day 11–13)
Egg Retrieval
Performed under mild IV sedation and lasts 15–30 minutes. Patients must fast beforehand and can typically return home after 1 hour of observation.
Sperm Collection
Sperm is collected on the same day or pre-frozen. The best sperm is selected via advanced lab procedures.
6. Fertilization and Embryo Culture
1. Fertilization Methods
- Standard IVF: For normal sperm quality
- ICSI (Intracytoplasmic Sperm Injection): For male infertility or poor sperm quality
2. Embryo Development
Embryos are cultured to Day 5 to reach the blastocyst stage, which improves implantation potential.
Some patients opt for PGT-A/PGT-M to test for chromosomal or genetic abnormalities.
3. Embryo Freezing
Once embryos reach the blastocyst stage, they are cryopreserved for future transfer.
7. Embryo Transfer Cycle
1. Frozen Embryo Transfer (FET)
Transfer can be done in a natural cycle or hormone replacement cycle, depending on the patient’s health and endometrial conditions.
2. Pre-Transfer Assessments
Doctors will evaluate:
- Uterine lining thickness
- Hormone levels
- Uterine conditions (e.g., fibroids, adhesions)
3. Embryo Transfer Procedure
A painless procedure (no anesthesia needed), where the embryo is gently placed into the uterus using a catheter. Rest is advised for 1–3 days afterward.
8. Pregnancy Test and Follow-Up Care
1. Pregnancy Confirmation
A blood test is done 9–12 days after transfer to check for hCG levels.
2. Continued Hormonal Support
If positive, progesterone and estrogen support continue until Week 10–12 of pregnancy.
3. Ongoing Care
You may continue follow-up care in the U.S. or return to your home country with your medical reports for continued support.
9. Common FAQs
Q1: Is the success rate of IVF in the U.S. high?
Yes. The average success rate for blastocyst transfer is 60–75%, and even higher when PGT is used.
Q2: Can more than one embryo be transferred?
Single embryo transfer is encouraged to avoid multiple pregnancies. Multiple transfers may be considered based on medical necessity.
Q3: Can I return home right after the embryo transfer?
It’s best to stay in the U.S. for 10–14 days after transfer to confirm pregnancy and monitor early development.
10. Summary
Although the U.S. IVF process involves multiple steps, it is well-structured and highly regulated. From medical evaluations and ovarian stimulation to embryo culture and transfer, every stage is guided by professional fertility teams.
If you’re planning to pursue IVF in the U.S., consulting experienced clinics like INCINTA Fertility Center can help tailor a plan suited to your unique situation and improve your chances of success.